2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (1900):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-176826
    3'-Bromo ANT-dGTP sodium salt
    3'-Bromo ANT-dGTP (3'-O-(5-Bromoanthraniloyl)-2'-deoxyguanosine-5'-O-triphosphate) sodium is a derivative of dGTP (HY-138616).
    3'-Bromo ANT-dGTP sodium salt
  • HY-112669R
    5-Chloro-2'-deoxyuridine (Standard)
    5-Chloro-2'-deoxyuridine (Standard) is the analytical standard of 5-Chloro-2'-deoxyuridine. This product is intended for research and analytical applications. 5-Chloro-2'-deoxyuridine, a thymine analog, is to study the potential of hypochlorous acid damage to DNA and DNA precursors.
    5-Chloro-2'-deoxyuridine (Standard)
  • HY-134352
    AA-UTP tetrasodium
    AA-UTP tetrasodium is an amine-modified nucleotide that can be directly incorporated into labeled-UTP (HY-107372).
    AA-UTP tetrasodium
  • HY-109014R
    Tenofovir exalidex (Standard)
    Tenofovir exalidex (Standard) is the analytical standard of Tenofovir exalidex. This product is intended for research and analytical applications. Tenofovir exalidex (CMX157) is a lipid conjugate of the acyclic nucleotide analog Tenofovir with activity against both wild-type and antiretroviral drug-resistant HIV strains, including multidrug nucleoside/nucleotide analog-resistant viruses. Tenofovir exalidex is active against all major subtypes of HIV-1 and HIV-2 in fresh human PBMCs and against all HIV-1 strains evaluated in monocyte-derived macrophages, with EC50s ranging between 0.2 and 7.2 nM. CMX157 is orally available and has no apparent toxicity. Tenofovir exalidex also shows antiviral activity against HBV.
    Tenofovir exalidex (Standard)
  • HY-115736B
    Xanthosine-5'-triphosphate lithium
    Xanthosine-5'-Triphosphate (5'-XTP) lithium, a nucleotide, is produced by deamination of purine bases. Xanthosine-5'-Triphosphate lithium is a substrate of inosine triphosphate pyrophosphatase (ITPase).
    Xanthosine-5'-triphosphate lithium
  • HY-16445A
    CNDAC
    		Inhibitor
    CNDAC is a metabolite of the orally active agent Sapacitabine (HY-16445), and a nucleoside analog. CNDAC induces DNA damage and apoptosis.
    CNDAC
  • HY-171529
    2′-OMe-UDP
    2′-OMe-UDP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    2′-OMe-UDP
  • HY-A0004S
    Decitabine-13C5
    Decitabine-13C5 (5-Aza-2'-deoxycytidine-13C5) is 13C labeled Decitabine. Decitabine (NSC 127716) is an orally active deoxycytidine analogue antimetabolite and a DNA methyltransferase inhibitor. Decitabine incorporates into DNA in place of cytosine can covalently trap DNA methyltransferase to DNA causing irreversible inhibition of the enzyme. Decitabine induces cell G2/M arrest and cell apoptosis. Decitabine has potent anticancer activity.
    Decitabine-<sup>13</sup>C<sub>5</sub>
  • HY-13701R
    Nelarabine (Standard)
    		Inhibitor
    Nelarabine (Standard) is the analytical standard of Nelarabine. This product is intended for research and analytical applications. Nelarabine (506U78) is a nucleoside analogue and can be used for the research of T cell acute lymphoblastic leukemia (T-ALL).
    Nelarabine (Standard)
  • HY-128710R
    2'-Fluorothymidine (Standard)
    2'-Fluorothymidine (Standard) is the analytical standard of 2'-Fluorothymidine. This product is intended for research and analytical applications. 2'-Fluorothymidine (2'-Fluoro-2'-deoxythymidine), a bioisostere of both thymidine (TdR) and methyluridine, is a putative highly selective substrate for thymidine kinase type 2 (TK2).
    2'-Fluorothymidine (Standard)
  • HY-154488
    3′-O-[(1,1-Dimethylethyl)dimethylsilyl]-2′-O-methyluridine
    3′-O-[(1,1-Dimethylethyl)dimethylsilyl]-2′-O-methyluridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents.
    3′-O-[(1,1-Dimethylethyl)dimethylsilyl]-2′-O-methyluridine
  • HY-116887R
    N6-Methyladenine (Standard)
    N6-Methyladenine (Standard) is the analytical standard of N6-Methyladenine (HY-116887). This product is intended for research and analytical applications. N6-Methyladenine is a modified purine that is widely present in prokaryotes. In prokaryotes, N6-Methyladenine plays an important role in distinguishing host DNA from exogenous DNA and controls many biological functions, such as DNA replication, transcription, mismatch repair, and chromosome replication. N6-Methyladenine can be used for the kidney diseases.
    N6-Methyladenine (Standard)
  • HY-173170
    Pseudouridine 5'-OTBDPS
    Pseudouridine 5'-OTBDPS (5-(5-O-TBDPS-β-D-ribofuranosyl)uracil) is an intermediate of Pseudouridine (HY-113061).
    Pseudouridine 5'-OTBDPS
  • HY-171534
    LNA-GTP
    LNA-GTP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    LNA-GTP
  • HY-171575
    3'-Amino-2',3'-dideoxy-ATP
    3'-Amino-2',3'-dideoxy-ATP is a modified nucleotide. 3'-Amino-2',3'-dideoxy-ATP can serve as a potent chain terminator for various DNA sequencing methods, including radioactive and fluorescent sequencing, and is compatible with multiple sequencing enzymes.
    3'-Amino-2',3'-dideoxy-ATP
  • HY-134314
    8-Nitro-cGMP
    8-Nitro-cGMP is an electrophilic second messenger of redox signaling that can form a protein-S-cGMP adduct in s-guanylation process. 8-Nitro-cGMP is an autophagy inducer. 8-Nitro-cGMP promotes RANKL-induced osteoclast differentiation from macrophages. 8-Nitro-cGMP has vasodilator effect, and ameliorates the vascular endothelial dysfunction in diabetic mice.
    8-Nitro-cGMP
  • HY-B0182R
    Carmofur (Standard)
    		Inhibitor
    Carmofur (Standard) is the analytical standard of Carmofur. This product is intended for research and analytical applications. Carmofur (HCFU) is a rat recombinant acid ceramidase inhibitor with an IC50 of 29 nM. Carmofur is also a protease inhibitor of SARS-CoV-2 main protease (Mpro), fatty acid amide hydrolase (FAAH) and N-acylethanolamine acid amidase (NAAA). Carmofur has anti-cancer, anti-inflammatory and anti-virus activities, and can be used for the study of COVID-19 and acute lung injury (ALI).
    Carmofur (Standard)
  • HY-157091
    Uridine, 5'-(P,P',P'',P''-tetrahydrogen imidotriphosphate)
    Uridine, 5'-(P,P',P'',P''-tetrahydrogen imidotriphosphate) is a non-hydrolyzable nucleotide that can synthesize RNA oligonucleotides.
    Uridine, 5'-(P,P',P'',P''-tetrahydrogen imidotriphosphate)
  • HY-171523
    LNA-GMP
    LNA-GMP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    LNA-GMP
  • HY-131799A
    3'-Amino-3'-deoxyadenosine-5'-O-diphosphate sodium
    3'-Amino-3'-deoxyadenosine-5'-O-diphosphate sodium is an amine-modified nucleotide that can be used in the synthesis of other active compounds. The coumarin-labeled derivatives of 3'-Amino-3'-deoxyadenosine-5'-O-diphosphate sodium exhibit significant fluorescence changes when interacting with myosin and can mimic the function of natural ADP.
    3'-Amino-3'-deoxyadenosine-5'-O-diphosphate sodium